AbD Serotec/Ustekinumab antibody | AbD17827_hIgG1/0.1 mg/HCA210P,AbD Serotec,,AbD Serotec,AbDSerotec,bio-rad-antibodies,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：AbD Serotec/Ustekinumab antibody | AbD17827_hIgG1/0.1 mg/HCA210P

产品编号：HCA210P

市场价：¥0.00

场地：美国(厂家直采)

产品分类：分子类>克隆和表达>转录表达>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：待定

品牌： AbD Serotec

公司：AbDSerotec

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商品介绍

Summary
Useful Reagents
References (1)

Human Anti-Ustekinumab Antibody, clone AbD17827_hIgG1 is a paratope specific, high affinity, anti-idiotypic antibody that specifically recognizes the monoclonal antibody drug ustekinumab and inhibits binding to its target. The antibody can be used to measure the levels of ustekinumab and biosimilar products in bioanalytical assays.Clone AbD17827_hIgG1 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or calibrator in an anti-drug antibody (ADA) assay. Additionally it can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug. This antibody is recommended as the detection antibody, paired with an anti-ustekinumab antibody in monovalent Fab format as the capture antibody, clone AbD17829 (HCA208) or clone AbD18334 (HCA209).Ustekinumab (Stelara) is a fully human monoclonal antibody drug (IgG1/kappa) that has been approved in US, Canada, and Europe for the treatment of plaque psoriasis and psoriatic arthritis. The FDA approved the medication for the treatment of moderate-severe Crohn"s disease in 2016. The drug blocks interleukin IL-12 and IL-23 by binding with high affinity and specificity to the p40 subunit, preventing the binding of these two cytokines to T-lymphocytes, and thereby disrupting the proinflammatory pathway.View a summary of all anti-ustekinumab antibodies

Product Details

Product Form: Human IgG1 antibody (kappa light chain) selected from the HuCAL® phage display library and expressed in a human cell line. Conjugated to horseradish peroxidase (HRP) - liquid.
Product Form: Human IgG1 antibody (kappa light chain) selected from the HuCAL® phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
Preparation: Purified IgG prepared by affinity chromatography on Protein A
Preparation: Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution: Phosphate buffered saline
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.01% Thiomersal
Preservative Stabilisers: 0.01% Thiomersal
Immunogen: Ustekinumab
Affinity: The monovalent intrinsic affinity of this antibody was measured as K_D=0.2 nM by real time, label-free molecular interaction analysis on immobilized ustekinumab.
Approx. Protein Concentrations: IgG concentration 0.1 mg/ml
Approx. Protein Concentrations: Pack Size: 0.1 mg
IgG concentration 0.5 mg/ml.
Pack Size: 1 mg
IgG concentration 1.0 mg/ml

Storage Information

Storage: Store at -70^oC.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
Storage: Store at +4^oC or at -20^oC if preferred.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee: 12 months from date of despatch
Guarantee: 12 months from date of despatch

More Information

Acknowledgements: Sold under license of U.S. Patents 6753136, 7785859 and 8273688 and corresponding patents. This antibody was developed by Bio-Rad, Zeppelinstr. 4, 82178 Puchheim, Germany.
Acknowledgements: Sold under license of U.S. Patents 6753136, 7785859 and 8273688 and corresponding patents. This antibody was developed by Bio-Rad, Zeppelinstr. 4, 82178 Puchheim, Germany.
Licensed Use: For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.
Regulatory: For research purposes only

Applications of Ustekinumab antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
ELISA
ELISA

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Technical Advice: Recommended protocols and further information about HuCAL recombinant antibody technology can be found in theHuCAL Antibodies Technical Manual
Technical Advice: Recommended protocols and further information about HuCAL recombinant antibody technology can be found in theHuCAL Antibodies Technical Manual
ELISA: This product may be used in a direct ELISA or as a detection antibody in a bridging ELISA together with AbD17829 (HCA208) or AbD18334 (HCA209) as the capture reagent. Protocol: PK bridging ELISA to measure free drug Protocol: PK bridging ELISA to measure free drug
ELISA: This product may be used in a direct ELISA or as a detection antibody, in its HRP conjugated format, in a bridging ELISA together with AbD17829 (HCA208) or AbD18334 (HCA209) as the capture reagent. Protocol: PK bridging ELISA to measure free drug Protocol: ADA bridging ELISA

Useful Reagents Available

Description	Product Code	Applications	Pack Size	Your Price	Quantity
Hispec Assay Diluent	BUF049A	E IY	50 ml	Log in	Get Quote
Human anti Ustekinumab	HCA208	E	0.1 mg	Log in	Get Quote
Human anti Ustekinumab	HCA209	E	0.1 mg	Log in	Get Quote
Hispec Assay Diluent	BUF049A	E IY	50 ml	Log in	Get Quote
Human anti Ustekinumab	HCA208	E	0.1 mg	Log in	Get Quote
Human anti Ustekinumab	HCA209	E	0.1 mg	Log in	Get Quote
LYNX Rapid HRP Antibody Conjugation Kit	LNK002P	CJ	3 Conjugations For 400µg Antibody	Log in	Get Quote