AbD Serotec/Cetuximab antibody | AbD19830_hIgG1/0.1 mg/HCA221P,AbD Serotec,,AbD Serotec,AbDSerotec,bio-rad-antibodies,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：AbD Serotec/Cetuximab antibody | AbD19830_hIgG1/0.1 mg/HCA221P

产品编号：HCA221P

市场价：¥0.00

场地：美国(厂家直采)

产品分类：分子类>克隆和表达>基因突变>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：待定

品牌： AbD Serotec

公司：AbDSerotec

公司分类：

商品介绍

Summary
Useful Reagents
References (1)

Human anti Cetuximab, clone AbD19830_hIgG1, is an anti-idiotypic antibody that binds specifically to cetuximab and inhibits the binding of the drug to its target. Human anti Cetuximab, clone AbD19830_hIgG1 can be used to measure the levels of cetuximab and biosimilar products using bioanalytical assays.In the HRP-conjugated format clone AbD19830_hIgG1 is ideal for use as detection antibody in pharmacokinetic (PK) assays. It is a fully human antibody and therefore may also be used as a calibrator in immune response assays to measure the anti-drug-antibody (ADA) response in patient sera.Cetuximab (brand name Erbitux®) is a chimeric monoclonal antibody drug (IgG1/kappa) approved for treatment of KRAS wild-type metastatic colorectal cancers and squamous cell carcinoma of the head and neck. This therapeutic antibody, directed against the Epidermal Growth Factor Receptor (EGFR), inhibits tumor cell proliferation by blocking the interaction of Epidermal Growth Factor (EGF) with its receptor.View a summary of all anti cetuximab antibodies.

Product Details

Product Form: Human IgG1 antibody (lambda light chain) selected from the HuCAL® phage display library and expressed in a human cell line. Conjugated to horseradish peroxidase (HRP) - liquid.
Product Form: Human IgG1 antibody (lambda light chain) selected from the HuCAL® phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
Preparation: Purified IgG prepared by affinity chromatography on Protein A
Preparation: Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution: Phosphate buffered saline
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.01% Thiomersal
Preservative Stabilisers: 0.01% Thiomersal
Immunogen: Cetuximab.
Affinity: The monovalent intrinsic affinity of HCA221 was measured as K_D=1.7 nM by real time, label free molecular interaction analysis on immobilized cetuximab.
Approx. Protein Concentrations: Total protein concentration 0.1 mg/ml
Approx. Protein Concentrations: IgG concentration 0.5 mg/ml

Storage Information

Storage: Store at -70^oC.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody.
Storage: Store at +4^oC or at -20^oC if preferred.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee: 12 months from date of despatch
Guarantee: 12 months from date of despatch

More Information

Acknowledgements: Sold under license of U.S. Patents 6753136, 7785859 and 8273688 and corresponding patents. This antibody was developed by Bio-Rad, Zeppelinstr. 4, 82178 Puchheim, Germany.
Acknowledgements: Sold under license of U.S. Patents 6753136, 7785859 and 8273688 and corresponding patents. This antibody was developed by Bio-Rad, Zeppelinstr. 4, 82178 Puchheim, Germany.
Licensed Use: For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.
Regulatory: For research purposes only

Applications of Cetuximab antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
ELISA
ELISA

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Technical Advice: Recommended protocols and further information about HuCAL recombinant antibody technology can be found in theHuCAL Antibodies Technical Manual
Technical Advice: Recommended protocols and further information about HuCAL recombinant antibody technology can be found in theHuCAL Antibodies Technical Manual
ELISA: This product may be used as a detection reagent in a bridging ELISA for PK assay development together with HCA220 as the capture reagent. Protocol: PK bridging ELISA to measure free drug
ELISA: This product may be used in a direct ELISA or as a bridging reagent in ADA assays. Following HRP-conjugation, this product can also be used as a detection reagent in a bridging ELISA for PK assay development together with HCA220 as the capture reagent. Protocol: PK bridging ELISA to measure free drugProtocol: ADA bridging ELISA

Useful Reagents Available

Description	Product Code	Applications	Pack Size	Your Price	Quantity
Hispec Assay Diluent	BUF049A	E IY	50 ml	Log in	Get Quote
Human anti Cetuximab	HCA220	E	0.1 mg	Log in	Get Quote
Hispec Assay Diluent	BUF049A	E IY	50 ml	Log in	Get Quote
Human anti Cetuximab	HCA220	E	0.1 mg	Log in	Get Quote
LYNX Rapid HRP Antibody Conjugation Kit	LNK002P	CJ	3 Conjugations For 400µg Antibody	Log in	Get Quote