AbD Serotec/Tocilizumab antibody | AbD21364_hIgG1/0.1 mg/HCA254,AbD Serotec,,AbD Serotec,AbDSerotec,bio-rad-antibodies,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：AbD Serotec/Tocilizumab antibody | AbD21364_hIgG1/0.1 mg/HCA254

产品编号：HCA254

市场价：¥0.00

场地：美国(厂家直采)

产品分类：分子类>克隆和表达>克隆基因>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：待定

品牌： AbD Serotec

公司：AbDSerotec

公司分类：

商品介绍

Summary
Useful Reagents

Human Anti-Tocilizumab Antibody, clone AbD21364_hIgG1 is a paratope specific, anti-idiotypic antibody that binds to free tocilizumab but not to human Interleukin-6 Receptor (IL-6R) or the drug/IL-6R complex. Clone AbD21364_hIgG1 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a surrogate positive control or calibrator (high affinity) in an anti-drug antibody (ADA) assay.Tocilizumab (RoActemra/Actemra) is a humanized IgG1/kappa monoclonal antibody approved for the treatment of moderate to severe rheumatoid arthritis and for the treatment of systemic juvenile idiopathic arthritis. The therapeutic antibody is directed against IL-6R and acts by blocking the binding of IL-6R (both the soluble form, sIL-6R, and the membrane bound form, mIL-6R) to IL-6, thus impeding the pro-inflammatory properties of this cytokine.View a summary of all anti-tocilizumab antibodies

Product Details

Product Form: Human IgG1 antibody (lambda light chain) selected from the HuCAL® phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
Preparation: Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.01% Thiomersal
Immunogen: Tocilizumab
Affinity: The monovalent intrinsic affinity of this antibody was measured as K_D = 0.3 nM by real time, label free molecular interaction analysis on immobilized tocilizumab.
Approx. Protein Concentrations: Antibody concentration 0.5 mg/ml

Storage Information

Storage: Store at +4^oC or at -20^oC if preferred.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use
Guarantee: 12 months from date of despatch

More Information

Acknowledgements: Sold under license of U.S. Patents 6753136, 7785859 and 8273688 and corresponding patents. This antibody was developed by Bio-Rad, Zeppelinstr. 4, 82178 Puchheim, Germany.Actemra® and RoActemra® are registered trademarks of Hoffman-La Roche and Chugai Pharmaceuticals co., Ltd.
Licensed Use: For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad
Regulatory: For research purposes only

Applications of Tocilizumab antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
ELISA

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Technical Advice: Recommended protocols and further information about HuCAL recombinant antibody technology can be found in theHuCAL Antibodies Technical Manual
ELISA: This product may be used in a direct ELISA or as a detection reagent in a bridging ELISA together with HCA252 as the capture reagent.Protocol: PK bridging ELISA to measure free drugThis antibody is fully human and can be used as a reference standard in an ADA assay.Protocol: ADA bridging ELISA

Useful Reagents Available

Description	Product Code	Applications	Pack Size	Your Price	Quantity
Hispec Assay Diluent	BUF049A	E IY	50 ml	Log in	Get Quote
Human anti Tocilizumab	HCA252	E*	0.1 mg	Log in	Get Quote
Human anti Tocilizumab	HCA253	E	0.1 mg	Log in	Get Quote
Human anti Tocilizumab	HCA255	E	0.1 mg	Log in	Get Quote
Human anti Tocilizumab	HCA256	E	0.1 mg	Log in	Get Quote
Human anti Tocilizumab	HCA257	E	0.1 mg	Log in	Get Quote
LYNX Rapid HRP Antibody Conjugation Kit	LNK001P	CJ	1 Conjugation For 400µg Antibody	Log in	Get Quote
LYNX Rapid HRP Antibody Conjugation Kit	LNK002P	CJ	3 Conjugations For 400µg Antibody	Log in	Get Quote
LYNX Rapid HRP Antibody Conjugation Kit	LNK003P	CJ	1 Conjugation For 4mg Antibody	Log in	Get Quote
LYNX Rapid HRP Antibody Conjugation Kit	LNK004P	CJ	5 Conjugations For 4mg Antibody	Log in	Get Quote
LYNX Rapid HRP Antibody Conjugation Kit	LNK005P	CJ	1 Conjugation For 20mg Antibody	Log in	Get Quote
LYNX Rapid HRP Antibody Conjugation Kit	LNK006P	CJ	3 Conjugations For 40µg Antibody	Log in	Get Quote